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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are often characterized as a focus on the practical aspects of designing a study, including the recruitment and 프라그마틱 공식홈페이지 consent process, as well as adherence and the use of standard equipment.
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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for pragmatic trials to be valid and lessen the chance of bias is also essential. However excessive heterogeneity could cause problems with the design of the trial.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by policymakers and practitioners in order to inform their decisions. They can be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used to substitute for explanatory studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials can be used to replace explanation tests or if they should be an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis and pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic study, including recruitment, design, implementation of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatics. However, it is important to note that the majority of these trials were conducted in primary care settings.