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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as focusing on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be valid and to reduce bias in the results is also essential. Too much heterogeneity, 프라그마틱 순위 however, can cause problems with the trial design.

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The purpose of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are usually commissioned by policymakers and practitioners to help guide their decisions. They can also be used to determine the cause-effect relationship of an intervention and its effects. However, they shouldn't be used in lieu for the use of explanation trials.

The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic study which includes recruitment, design, delivery of the intervention and its follow-up.

There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatism. However, it is important to remember that the majority of these trials were conducted in primary care settings.