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Pragmatic trials are trials designed to inform real-world clinical practice. They are usually characterized by a focus on practical aspects of the study design, such as the recruitment process and consent in adherence, as well as the use of commonly available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be valid and reduce bias in results is also essential. Too much heterogeneity, however, can cause problems with the design of the trial.
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The aim of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. Usually, they are ordered by policymakers and practitioners in order to guide their decisions. They can be used to determine the causality of an intervention with its outcomes. However, they should not be used to substitute for explanation studies.
The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or clinical hypothesis and pragmatic trials, which inform the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study which includes recruitment, design, delivery of the intervention, and follow-up.
There is a growing increase in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, 프라그마틱 이미지 limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority of these trials were conducted in primary care settings.