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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are usually focused on the practical aspects of the research design, like the recruitment process and consent, adherence, and the use of standard equipment.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be valid and to reduce bias in the results, is also necessary. However too much heterogeneity could result in issues with the design of the trial.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policymakers to guide their decisions. They can also be used to determine the causal relationship between an intervention and its results. However, they should not be used to substitute for explanation trials.

The idea of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should serve as an addition to them. Schwartz and 프라그마틱 정품확인 Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis and pragmatic trials, which inform the policy and practice of. They also proposed the framework for pragmatic trials, 프라그마틱 슬롯 하는법 (Instapaper.com) called PRECIS.2 This tool attempted to define the elements of a pragmatic study that include the recruitment process, the design and delivery of the intervention, and monitoring.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.